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Farmacodinamica
Il fenomeno dell’erezione è dovuto ad un rilassamento della muscolatura liscia dei corpi cavernosi del pene cui segue una vasodilatazione arteriosa. La parallela costrizione dei vasi venosi determina ristagno di sangue cui segue l’erezione. Il rilassamento dei muscoli lisci dei corpi cavernosi è un fenomeno mediato dall’ossido di azoto (NO). Esso attiva l’enzima guanilato ciclasi […]

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El Sildenafil (compuesto UK-92,480) fué sintetizado por un grupo de químicos farmaceúticos de la Empresa Pfizer, en las instalaciones de investigación en Sandwich, Kent.]] Inicialmente fué estudiado para su uso en hipertensión (alta presión sanguínea), y angina de pecho (una forma de enfermedad cardiovascular isquémica). La Fase I juicios clínicos bajo la dirección de Ian […]

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Wirkmechanismus
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Viagra Pfizer ist ein potenter selektiver Hemmer der […]